Question: ‘Does a child's diet have anything to do with
ADHD?
Dr. Spencer: Your question about diet was
actually
formally studied. Everybody had the impression that diet was closely
related.
If diet was to be a cause of the problem, then if you changed diet,
then
people would get better, and it hasn’t been shown to be true.
Kids
with ADHD tend to crave junk food and sugar. They eat poorly. If you
eat
a lot of sugar, you’re a little more hyper, but even if you exclude
sugar
and all these additives and eat a very bland, difficult-to-enforce
diet,
you don’t improve that much. That was actually tested. There were lots
of
double-blind controlled studies of that. The American Academy of
Pediatrics
wrote a position statement saying that there may be a few sensitive
individuals,
but by and large, diet isn’t a good treatment for ADHD, and it's not
usually
part of the cause.’
Response:
Food dyes impair performance of hyperactive children on
a laboratory learning test.
‘Forty children were given a diet free of
artificial
food dyes and other additives for 5 days. Twenty of the children had
been
classified as hyperactive by scores on the Conners Rating Scale and
were
reported to have favorable responses to stimulant medication. A
diagnosis
of hyperactivity had been rejected in the other 20 children. Oral
challenges
with large doses (100 or 150 milligrams) of a blend of FD & C
approved
food dyes or placebo were administered on days 4 and 5 of the
experiment.
The performance of the hyperactive children on paired-associate
learning
tests on the day they received the dye blend was impaired relative to
their
performance after they received the placebo, but the performance of the
nonhyperactive
group was not affected by the challenge with the food dye blend.’
[Swanson J.M., Kinsbourne M., Science. 1980 Mar
28;207(4438):1485-7]
Synthetic food colourings and 'hyperactivity': a
double-blind
crossover study.
‘Of 220 children referred for suspected
'hyperactivity',
55 were subjected to a 6 week trial of the Feingold diet. Forty (72.7%)
demonstrated
improved behaviour and 26 (47.3%) remained improved following
liberalization
of the diet over a period of 3-6 months. The parents of 14 children
claimed
that a particular cluster of behaviours was associated with the
ingestion
of foods containing synthetic colourings. A double-blind crossover
study,
employing a single-subject repeated measures design was conducted,
using
eight of these children. Subjects were maintained on a diet free from
synthetic
additives and were challenged daily for 18 weeks with either placebo
(during
lead-in and washout periods) or 50 mg of either tartrazine or
carmoisine,
each for 2 separate weeks. Two significant reactors were identified
whose
behavioural pattern featured extreme irritability, restlessness and
sleep
disturbance. One of the reactors did not have inattention as a feature.
The
findings raise the issue of whether the strict criteria for inclusion
in
studies concerned with 'hyperactivity' based on 'attention deficit
disorder'
may miss children who indicate behavioural changes associated with the
ingestion
of food colourings. Moreover, for further studies, the need to
construct
a behavioural rating instrument specifically validated for dye
challenge
is suggested.’
[Rowe KS. Department of Paediatrics, Royal Children's
Hospital,
Parkville, Victoria, Australia. Aust Paediatr J. 1988 Apr;24(2):143-7]
Synthetic food colouring and behaviour: a dose response
effect in a double-blind, placebo-controlled, repeated-measures study.
‘Sensitivity to food colors and flavors:
This study demonstrated a functional relation between the ingestion of
a
synthetic food color (tartrazine) and behavioral change in 24 atopic
(allergic)
children, with marked reactions being observed at all six dosage levels
of
dye challenge. When they reacted to the (food) dye, the younger
children
had constant crying, tantrums, irritability, restlessness, severe sleep
disturbance,
and were described as 'out-of-control, easily distracted and excited,
and
high as a kite.’
[Rowe, K.S. and Rowe K.L. (1994) Journal of Pediatrics
(125),691-8]
Oligo-antigenic diet treatment of children with epilepsy
and migraine
’We studied the role of oligo-antigenic diets
in 63 children with epilepsy; 45 children had epilepsy with migraine,
hyperkinetic
behavior, or both, and 18 had epilepsy alone. Of the 45 children who
had
epilepsy with recurrent headaches, abdominal symptoms, or hyperkinetic
behavior,
25 ceased to have seizures and 11 had fewer seizures during diet
therapy.
Headaches, abdominal pains, and hyperkinetic behavior ceased in all
those
whose seizures ceased, and in some of those whose seizures did not
cease.
Foods provoking symptoms were identified by systematic reintroduction
of
foods, one by one; symptoms recurred with 42 foods, and seizures
recurred
with 31; most children reacted to several foods. Of 24 children with
generalized
epilepsy, 18 recovered or improved (including 4 of 7 with myoclonic
seizures
and all with petit mal), as did 18 of 21 children with partial
epilepsy.
In double-blind, placebo-controlled provocation studies, symptoms
recurred
in 15 of 16 children, including seizures in eight; none recurred when
placebo
was given. Eighteen other children, who had epilepsy alone, were
similarly
treated with an oligoantigenic diet; none improved.’
[J Pediatr. 1990 Sep;117(3):509-10.. Egger J, Carter CM,
Soothill JF, Wilson J. Department of Neurology, Hospital for Sick
Children,
London.]
The Health of Criminals Related to Behaviour, Food,
Allergy and Nutrition: A Controlled Study of 100 Persistent Young
Offenders
‘This questionnaire-based research addressed
the young offender population in order to estimate the proportion
likely
to have food allergic and other nutritionally related disorders such as
hyperactivity.
A controlled health and dietary survey was conducted with 100 young
offenders
and 100 matched non-offenders. The offender group reported
significantly
higher rates of ill health than the non-offender group. It is suggested
that
the nutritional health of young offenders could be investigated as part
of
present statutory requirements to consider the physical and mental
health
of young criminals. There was no real difference between the diets of
the
two groups. Further research is justified into the association between
nutrition,
health and behaviour problems. From this study, the proportion of the
persistent
young offender population with maladaptive behaviours linked to food
allergy,
food intolerance and nutritional problems is cautiously estimated to be
75%
whereas 18% of the young non-offender population is similarly affected.’
[C. Peter, W. Bennett ; Jonathan Brostoff ; Journal of
Nutritional & Environmental Medicine 7:4:359 – 366]
Can treating food allergies prevent antisocial
behavior?
‘Poor health and nutritional problems are common among young criminals.
New
research indicates that the link is more than coincidental, and that
treating
health and diet problems may be one key to preventing behavioral
problems
and even criminality.
‘Sick’ offenders
Several years ago, C. Peter Bennett
and Jonathan Brostoff surveyed 100 young offenders and 100 matched
non-offenders,
and found that ‘the offender group reported significantly higher rates
of
ill health than the non-offender group.’ For instance, offenders were
far
more likely than controls to report stomach-aches, lethargy, eye and
nose
problems, poor sleep, abnormal thirst, poor concentration, and poor
memory,
and to be hyperactive. Noting that many symptoms exhibited by the
offenders
could be linked to food allergies or food intolerance, Bennett et al.
recently
tested the effects of nutritional interventions on young criminals.
Their
research involved nine children, between the ages of 7 and 16, with
histories
of ‘persistent anti-social, disruptive and/or criminal behaviors.’
Bennett
et al. say their nine subjects had collectively committed 67 crimes,
and
note that ‘all the subjects regularly displayed irrational aggression
and
violence.’
Physicians identified nutrient deficiencies and food allergies
in
all nine of the subjects, and elevated levels of cadmium - a
neuro-toxic
heavy metal - in four. The researchers provided treatment for all
subjects,
including dietary restriction and allergy desensitization therapy.
Videos shot by an independent BBC film crew before the
intervention,
the researchers say, ‘showed uncontrolled, violent, competitive and
anti-social
behavior.’ Afterward, in contrast, participants were ‘controlled,
cooperative
and sociable.’
Bennett et al. say that the health and behavior of all nine
subjects
improved during treatment. Three children later discontinued the
dietary
intervention, and two re-offended. Of the six other subjects, two
re-offended,
‘but with much reduced frequency and violence than before the project.’
In
all, of nine subjects, five did not re-offend during the two years
following
the intervention.
The researchers conclude that dietary intervention ‘appears to
work
within an ethical, efficient, effective, economical and preventive
paradigm
without harm.’
Color me hyper
Research by Neil Ward links hyperactivity
- a strong risk factor for criminality - to nutritional deficiencies
and
food intolerance. Ward surveyed the parents of 486 hyperactive children
and
172 non-hyperactive controls. The parents of the hyperactive children
reported
that more than 60% exhibited increased behavior problems when exposed
to
synthetic colorings and flavorings, preservatives, cow's milk, and
certain
chemicals. In contrast only 12% of parents of the controls reported a
connection
between food additives or colorings and worsened behavior.
Ward identified a subgroup of hyperactive children with known
sensitivities
to synthetic food colors, and exposed the children to these chemicals.
Of
23 exposed to the food coloring tartrazine, 18 responded by becoming
overactive,
16 became aggressive, 4 became violent, and several developed eczema,
asthma,
poor speech, or poor coordination. In contrast, only one control
subject
showed minor behavioral changes after drinking tartrazine. Two other
colorings,
‘sunset yellow’ and amaranth, also caused significant behavioral
effects
in hyperactive subjects.
Ward uncovered one possible explanation for the food colorings’
effects.
The hyperactive children in the study had statistically lower zinc and
iron
levels than controls - and when hyperactive children known to be
sensitive
to the colorings tartrazine and ‘sunset yellow’ were exposed to these
chemicals,
their blood serum zinc levels dropped markedly. ‘Several studies,’ Ward
notes,
‘have shown that zinc-deficient animals are more prone to stress and
are
aggressive when compared with normal cases.’ Previous research also has
strongly
linked tartrazine to hyperactivity.
(see related article, Crime Times, 1995, Vol. 1,
No. 3, Page 5).
Dr. Christie C. Yerby, Doctor of
Naturopathic Medicine writes in her article ‘To Die For’: ‘It is
amazing
the amount of toxins that are in some nutritional supplements these
days.
Perhaps it was by the example of the food industry that originally
sanctioned
it as being OK, that other industries feel that they can follow. Now,
even
some of our nutritional supplements, the sacred resource we have
trusted
as being “good for us”, is causing concern. What we eat as food,
swallow
as supplement and drug pill coatings or medicinal syrups, or rub on
ourselves
as cosmetics often contain toxic coal-tar based dyes. According to
several
resources on the subject, four of these dyes, Red 3, Yellow 5, Yellow
6,
and Blue 2 have been shown to cause cancer, as have other dyes which
are
not used in food, but are used in drugs or cosmetics. Fortunately, the
history
of food dyes in the U.S. is one of “decreasing” rather than
“increasing.”
Of the 24 food dyes previously allowed in the American food supply, 17
are
now banned, de-listed, or no longer produced. We are, however, still
waiting
for the other seven to be removed from consumer products by the FDA.
Until
then, we continue to consume them. Toxicity of three dyes (Red 3,
Yellow
5, and Yellow 6) is the subject of a Public Citizen Health Research
Group
petition to the FDA, calling for a ban. The group is now also reviewing
the
safety studies on the other four dyes (Green 3, Red 40, Blue 1, and
Blue
2), because of previous toxic findings. FD and C Blue No. 2 was shown
to
produce malignant tumors at the site of injection when introduced under
the
skin of rats. The World Health Organization gives it a toxicology
rating
of B, meaning that data was not sufficient to make it acceptable for
food
use. FD and C Yellow No. 6 is used in food, alcohol, supplements,
cosmetics,
and hair rinses. In 1986, the FDA passed a ruling that it had to be
listed
on the labels because of its ability to cause allergic reactions. Don’t
be
fooled, though. Check your one-a-day “A to Zs” and you will note that
the
dyes are listed only on the throw-away box, and not on the inside
bottle
itself. Tests conducted on FD and C Red No. 40 were all conducted by
its
manufacturer, (name withheld). Consequently, many American scientists
feel
that the safety of Red No. 40 is far from established. The National
Cancer
Institute reported that p-cresidine, a chemical used in preparation of
Red.
No. 40, was carcinogenic in animals. In rats, a high dose caused
adverse
reproductive effects. Aspirin-sensitive patients have been reported to
develop
life-threatening asthmatic symptoms when ingesting Yellow No. 5. By
law,
it too is supposed to be on the label when added to a product. But,
again,
many products do not reflect these additives if the lists of
ingredients
are not labeled directly on the bottle itself. Watch for this. Of
particular
interest, these toxic dyes are not only being read from the labels of
junk
foods, candies, and fertilizers, they are coming right off the outside
boxes
of a popular multivitamin for kids. Oh, and one more interesting thing,
it
adds near the bottom: “Keep out of reach of children.”’
New England Journal of Medicine October
5, 2000; 343; 1047-1048:
‘A common blue food dye seems
to have caused the deaths of 2 patients after it was used to color the
liquid
food pumped into their stomachs, according to a new report in the New
England
Journal of Medicine. The patients had been given food with FD&C
blue
dye No. 1, after which their skin and blood turned a bluish-green.
Several
hours later the patients, a 12 month old with Down's Syndrome and a 54
year
old with kidney failure, were dead. The blue dye, made of coal tar, is
routinely
added to the liquid food to help doctors see whether any of the food is
escaping
from the stomach. In healthy people, the food and the dye are not
thought
to leave the digestive tract. The three cases involved patients
who
had digestive track tissues being destroyed by sepsis, a serious
infectious
condition. The condition apparently allowed the dye to enter the
bloodstream,
causing a deadly drop in blood pressure (hypotension) and an increase
in
acid levels in the body's fluids and tissues (acidosis). According to
the
researchers: “During sepsis, gastrointestinal permeability increases
because
of enterocyte death and loss of barrier function at intercellular gaps.
Thus,
substances that are otherwise nonabsorbable may be absorbed during
sepsis.”
The researchers note that Blue dye #1 was approved by the FDA in
1982
after experiments in healthy animals indicated that the dye was
nontoxic
and not absorbed. Concerning the potential health dangers of the dye,
the
authors state:
“Blue dye no. 1, a triphenylmethane dye, is a potent inhibitor
of
mitochondrial respiration in vitro and reduces oxygen consumption by a
factor
of eight in mitochondrial preparations in vitro. It appears to inhibit
energy
transformation by blocking the adenine nucleotide translocator (as is
the
case with atractyloside).”
The researchers note that although both patients were
hospitalized
with serious illnesses, their condition was improving before they
received
the dye. Although researchers say the dye is not dangerous to the vast
majority
of people, they are recommending “judicious use” in patients with
possible
increased gastrointestinal permeability.’
Lost study links food additives to tantrums.
By Robert Uhlig Food Correspondent (Filed: 25/10/2002):
‘Lost study links food additives
to tantrums: Parents were left confused last night after a
Government-sponsored
study appeared to show that food colourings and additives used in some
200
popular foods caused temper tantrums and hyperactivity up to a quarter
of
young children. The study, commissioned three years ago by the former
Ministry
of Agriculture and completed last year, was discovered by food
campaigners
in the library of the Food Standards Agency. It appeared to be the
first
time that a Government-sponsored study had corroborated anecdotal
evidence
of a link between food additivies and changes in children’s mood and
behaviour.
The Food Standards Agency said the study was “in line with previous
reports
by other organisations” but had been dismissed by experts on its
scientific
and medical panel as “scientifically inconclusive”. Having been
rejected
by several peer-reviewed journals, the report by scientists at the
Asthma
and Allergy Research Centre lacks the science world's stamp of approval.
Nevertheless the Food Commission, which unearthed the study,
said
parents should take close notice because the study concluded that
“significant
changes in children's hyperactive behaviour could be produced by the
removal
of colourings and additives from their diet”.
The food additives were tested on 277 three-year-olds from the Isle of
Wight
using scientifically valid double blind tests. However, the research
was
deemed by the Food Standards Agency not to be scientifically objective
because
it relied on parents recording significant changes in their children's
behaviour.
The artificial food colourings Tartrazine (E102), Sunset Yellow (E110),
Carmoisine
(E122), and Ponceau 4R (E124) and the preservative Sodium Benzoate
(E211)
were given in a single drink. The test dose of colourings in the trial
was
well below levels permitted in children's foods and drinks. For the
preservative,
the test dose was equal to the permitted level. Parents described
behaviour
such as “interrupting”, “fiddling with objects”, “disturbing others”,
“difficulty
settling down to sleep”, “no concentration” and “temper tantrums”.
Following the study, the Food Commission found more than 200
children's
foods and drinks containing one or more of the additives. The products
included
well-known fizzy drinks, sweets, canned vegetables, cakes, biscuits,
puddings,
sauces, crisps and ice lollies.
Annie Seeley, a nutritionist at the Food Commission, said nearly 40 per
cent
of children’s food and drinks contained additives. Kath Dalmeny,
research
officer at the commission, which publishes the findings in Food
Magazine
today, said it was “concerned to find it has been rejected by several
peer-reviewed
journals”. She said: “Any study involving children often relies on
parental
observation. Taking children out of their home environment or having
them
observed by strangers can itself affect the results.” Dr Hasan Arshad,
director
of the David Hide Asthma and Allergy Research Centre, which undertook
the
study, defended its findings. He said it provided the first results
from
a large-scale trial.’
References and
other relevant literature:
The Shipley Project: treating food
allergy to prevent criminal behaviour in community settings; C. Peter,
W.
Bennett et al; Journal of Nutritional and Environmental Medicine, Vol.
8,
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The health of criminals related to behaviour, food, allergy and
nutrition:
a controlled study of 100 persistent young offenders; C. Peter, W.
Bennett
and Jonathan Brostoff;, Journal of Nutritional and Environmental
Medicine,
Vol. 7, 1997, pp. 359- 366.
Assessment of chemical factors in
relation to child hyperactivity; Neil Ward, Journal of Nutritional and
Environmental
Medicine, Vol. 7, 1997, pp. 333-342.
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www.mcspotlight.org, about McDonalds
www.rachel.org, newsletter #712, summary
of Children in harm's way: toxic threats to child development,
see Schettler.